• Publications

  2013

  C1q-induced LRP1B and GPR6 proteins, expressed early in Alzheimer’s disease models, are essential for the C1q-mediated protection against amyloid-ß neurotoxicity. Benoit ME, Hernandez MX, Dinh ML, Benavente F, Vasquez O, Tenner AJ. J Bio Chem 2013 Jan 4,288(1):654-65.

  Complement activation fragment C5a receptors, CD88 and C5L2, are associated with neurofibrillary pathology. J Neuroinflamm. Accepted 2013.

  2012

  Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study. Cribbs DH, Berchtold NC, Perreau V, Coleman PD, Rogers J, Tenner AJ, Cotman, CW. J Neurinflammation. 2012 Jul 23;9:179.

  2011

  Presenilins mediate efficient proteolysis via the autophagosome-lysosome system. Neely KM, Green KN. Autophagy. 2011 Jun 1;7(6).

  Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia. Koike MA, Garcia FG, Kitazawa M, Green KN, Laferla FM. Neurosci Lett. 2011 Mar 23.

  ST101 induces a novel 17kDa APP cleavage that precludes Aβ generation in vivo. Green KN, Khashwji H, Estrada T, Laferla FM. Ann Neurol. 2011 Mar 17

  Presenilin Is Necessary for Efficient Proteolysis through the Autophagy-Lysosome System in a {gamma}-Secretase-Independent Manner. Neely KM, Green KN, Laferla FM.  J Neurosci. 2011 Feb 23;31(8):2781-91.

  Age and distraction are determinants of performance on a novel visual search task in aged Beagle dogs. Snigdha S, Christie LA, De Rivera C, Araujo JA, Milgram NW, Cotman CW. Age (Dordr). 2011 Feb 19.

  HDAC inhibition modulates hippocampus-dependent long-term memory for object location in a CBP-dependent manner. Haettig J, Stefanko DP, Multani ML, Figueroa DX, McQuown SC, Wood MA. Learn Mem. 2011 Jan 11;18(2):71-9.

  A role for thrombospondin-1 deficits in astrocyte-mediated spine and synaptic pathology in Down’s syndrome. Garcia O, Torres M, Helguera P, Coskun P, Busciglio J. PLoS One. 2010 Dec 2;5(12):e14200.

  Plasma amyloid-β as a function of age, level of intellectual disability, and presence of dementia in Down syndrome. Head E, Doran E, Nistor M, Hill M, Schmitt FA, Haier RJ, Lott IT. J Alzheimers Dis. 2011 Jan 1;23(3):399-409.

  Complement protein C1q-mediated neuroprotection is correlated with regulation of neuronal gene and microRNA expression. Benoit ME, Tenner AJ. J Neurosci. Mar 2;31(9):3459-3469.

  Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer’s disease. Fonesca MI, Chu SH, Berci AM, Benoit ME, Peters DG, Kimura Y, Tenner AJ. J Neuroinflammation. 2011 Jan 158(1):4.

  Complement in the brain. Veerhuis R, Nielsen HM, Tenner AJ. Mol Immunol. 2011 Aug;48(14):1592-603.

  2010

  Formulation of a medical food cocktail for Alzheimer’s disease: beneficial effects on cognition and neuropathology in a mouse model of the disease. Parachikova A, Green KN, Hendrix C, LaFerla FM. PLoS One. 2010 Nov 17;5(11):e14015.

  Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy. Vasilevko V, Passos GF, Quiring D, Head E, Kim RC, Fisher M, Cribbs DH. Ann N Y Acad Sci. 2010 Oct;1207:58-70.

  Pathways linking Abeta and tau pathologies. LaFerla FM. Biochem Soc Trans. 2010 Aug;38(4):993-5.

  Abnormal EEGs in cognitively and physically healthy oldest old: findings from the 90+ study. Peltz CB, Kim HL, Kawas CH. J Clin Neurophysiol. 2010 Aug;27(4):292-5.

  Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation. Parachikova A, Vasilevko V, Cribbs DH, LaFerla FM, Green KN. J Alzheimers Dis. 2010;21(2):527-42.

  The Role of Tau in Alzheimer’s disease and related disorders. Medeiros R, Baglietto-Vargas D, Laferla FM. CNS Neurosci Ther. 2010 Jun 14.

  Cognitive deficits and associated neurological complications in individuals with Down’s syndrome. Lott IT, Dierssen M. Lancet Neurol. 2010 Jun;9(6):623-33.

  Oligemic hypoperfusion differentially affects tau and amyloid-{beta}. Koike MA, Green KN, Blurton-Jones M, Laferla FM. Am J Pathol. 2010 Jul;177(1):300-10.

  Memantine improves cognition and reduces Alzheimer’s-like neuropathology in transgenic mice. Martinez-Coria H, Green KN, Billings LM, Kitazawa M, Albrecht M, Rammes G, Parsons CG, Gupta S, Banerjee P, LaFerla FM. Am J Pathol. 2010 Feb;176(2):870-80.

  IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. Thompson LM, Aiken CT, Kaltenbach LS, Agrawal N, Illes K, Khoshnan A, Martinez-Vincente M, Arrasate M, O’Rourke JG, Khashwji H, Lukacsovich T, Zhu YZ, Lau AL, Massey A, Hayden MR, Zeitlin SO, Finkbeiner S, Green KN, LaFerla FM, Bates G, Huang L, Patterson PH, Lo DC, Cuervo AM, Marsh JL, Steffan JS.J Cell Biol. 2009 Dec 28;187(7):1083-99.

  Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta. Vasilevko V, Pop V, Kim HJ, Saing T, Glabe CC, Milton S, Barrett EG, Cotman CW, Cribbs DH, Head E. Neurobiol Dis. 2010 Sep;39(3):301-10.

  Abeta aggregation profiles and shifts in APP processing favor amyloidogenesis in canines. Pop V, Head E, Berchtold NC, Glabe CG, Studzinski CM, Weidner AM, Murphy MP, Cotman CW. Neurobiol Aging. 2010 Apr 29.

  Abeta DNA vaccination for Alzheimer’s disease: focus on disease prevention. Cribbs DH. CNS Neurol Disord Drug Targets. 2010 Apr;9(2):207-16.

  Microglial C5aR (CD88) expression correlates with amyloid deposition in murine models of Alzheimer’s disease. Ager RR, Fonseca MI, Chu S, Sanderson S, Taylor SM, Woodruff TM, Tenner AJ. J Neurochem.  2010 Apr;113(2):389-401

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