Home Calendar of Events Clinical Programs Clinical Trials Education & Training Research Graduate & Post Doctoral Training Newsletters About the Institute Support the Institute Frequently Asked Questions Graduate & Post Doctoral Training Mission Statement Training Statement Main Areas of Research Training Neurobiology Aging Track Preceptors & Recent Interests Disclaimer University of California, Irvine Check all • Clear all • View Selected Preceptors Tallie Z.  Baram,  M.D., Ph.D.,  Professor of Pediatrics, Anatomy/Neurobiology and Neurology: Developmental events on aging, specifically the consequences of excessive secretion of CRH (corticotropon releasing hormone) early in life on the structure and function of the mature and aging hippocampus. Richard  Chamberlin,  Ph.D.,  Professor of Chemistry: Molecular modeling and organic synthesis to investigate age-related issues, e.g. synthesis of excitatory amino acid receptor analogues. Carl W.  Cotman,  Ph.D.,  Professor of Neurology, Neurobiology and Behavior, Director for the Institute for Brain Aging and Dementia: Development of interventions to promote successful aging in animal models or humans; mechanisms causing neuronal degeneration in Alzheimer’s disease (AD). Christine M.  Gall,  Ph.D.,  Professor of Anatomy and Neurobiology: Age related regulation and expression of neurotrophic factors linked to processes of axons sprouting in brain; i.e., the fibroblast growth factors (FGF), ciliary neurotrophic factor (CNTF), and insulin-like growth factor-1 (IGF-1). Charles  Glabe,  Ph.D.,  Professor of Molecular Biology and Biochemistry: The pathway of amyloid fibril assembly using a variety of biophysical and spectroscopic techniques; the cellular mechanisms of amyloid pathogenesis in Alzheimer's disease. Noo Li  Jeon,  Ph.D.,  Assistant Professor of Biomedical Engineering: Development of novel micro devices that integrate live cells (i.e. neurons) with micro fluidics (manipulation and movement of small amount of fluids inside the channels). Claudia H.  Kawas,  M.D.,  Professor of Neurology and Neurobiology and Behavior: Clinical research on the cognitive and functional abilities of the oldest old (over 90 years of age), and the prevention of Alzheimer’s disease. Hans  Keirstead,  Ph.D.,  Assistant Professor of Anatomy and Neurobiology: The development of strategies to limit degeneration and enhance regeneration after spinal cord injury and the way how aging affects recovery from CNS injury. Frank M.  LaFerla,  Ph.D.,  Associate Professor of Neurobiology and Behavior: On the contributions of presenilin mutations to neuronal function; the development of new transgenic models. Jiankang   Liu,  Ph.D.,  Associate Research Professor: Dr. Liu's research interests include studies molecular and cellular mechanisms of aging, stress, and age-/stress-associated degenerative diseases, with a focus on mitochondrial targeting nutrients on mitochondrial metabolism. Gary  Lynch,  Ph.D.,  Professor of Psychiatry: Studies to identify potential therapeutics for the amyloid deposition in Alzheimer’s disease; age-related changes in synaptic adhesion molecules involved in the emergence of amyloid toxicity in the aged brain. John F.  Marshall,  Ph.D.,  Professor of Neurobiology and Behavior: The function of the basal ganglia in relationship to aging and neurodegenerative diseases. James L.  McGaugh,  Ph.D.,  Professor of Neurobiology and Behavior: Neuromodulatory systems (including hormones, neurotransmitters and brain systems) in the regulation of memory storage. Orhan  Nalcioglu,  M.D.,  Professor of Radiology: The use of three-dimensional imaging techniques to quantify brain perfusion using dynamic contrast enhanced MRI and brain function using 3D functional MRI (3D-fMRI) in aged higher animal models and humans. James S.  Nowick,  Ph.D.,  Professor of Chemistry: Organic chemistry of ß-sheet formation including the development of unique unnatural amino acid building blocks that make peptides participate in beta-sheet interactions. Thomas  Poulos,  Ph.D.,  Professor of Molecular Biology and Biochemistry: The investigation of the molecular structure of proteins and peptide involved in brain aging. Philip  Sheu,  Ph.D.,  Associate Professor of Computer Science and Electrical Engineering: The application and management of object-oriented databases for brain aging and dementia. Padhraic J.  Smyth,  Ph.D.,  Associate Professor of Information and Computer Science: NA Arnold  Starr,  M.D.,  Professor of Neurology: The neurobiological basis of cognitive changes that accompany aging and Alzheimer’s disease using evoked potential analysis; the early detection of Alzheimer’s disease. Andrea  Tenner,  Ph.D.,  Professor of Molecular Biology and Biochemistry: Dysregulation and dysfunction of immune processes and the role of complement and inflammation in Alzheimer's disease (AD). Douglas C.  Wallace,  Ph.D.,  Professor of Biological Chemistry and Ecology and Evolutionary Biology, Director of the Center for Molecular and Mitochondrial Medicine and Genetics: The genetics of the human mitochondrion, and the role of mitochondrial variation in human evolution, degenerative disease, and aging. John H.  Weiss,  M.D., Ph.D.,  Associate Professor of Neurology: Basic cellular mechanisms that contribute to the neurodegeneration that occurs in aging-related diseases, particularly as relates to zinc and mitochondrial function. Qun-Yung  Zhou,  Ph.D.,  Assistant Professor of Pharmacology: The dopamine system and dopamine transporters in Parkinson’s disease. Check all • Clear all • View Selected Preceptors Home • Calendar of Events • Clinical Programs • Clinical Trials • Education & Training • Research Graduate & Post-Doctoral Training • Newsletters • About the Institute • Support the Institute • Frequently Asked Questions

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