Pilot Projects

2013 Pilot Projects

Project 1:
Epigenetic Modulation of H3Ke4me3 Mark as a Therapeutic Target for Alzheimer’s Disease
Project Leader: Leslie Thompson, Ph.D.



This study directly targets a biologically relevant epigenetic signature that may be an effective strategy for therapeutic intervention in Alzheimer’s disease. Given the high incidence of Alzheimer’s disease in human population which is increasing with aging populations, this work has significant relevance to public health. Further, this work may have broad therapeutic potential for other neurodegenerative diseases
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Project 2:
Lipoxin A4 as Potential Biomarker and Treatment for Alzheimer’s Disease
Project Leader: Rodrigo Medieros

Inflammation plays both a protective and damaging role in Alzheimer’s disease, so to identify a long-lasting and effective treatment, it is important that we better understand the disease’s underlying processes. This project investigates the molecular mechanisms associated with the age-dependent imbalance between pro-inflammatory and anti-inflammatory/pro-resolution lipid pathways in AD. These studies may establish the lipoxin A4 pathway as an attractive target for the development of a novel biomarker and therapy for Alzheimer’s disease.


The UC Irvine ADRC CORE COMPONENTS

Clinical
Helps families affected by Mild Cognitive Impairment (MCI), Alzheimer's disease, or another dementia while gathering invaluable research data about the clinical presentation and progression of these cognitive disorders.
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Education and Information
Garners community involvement in research, combats the widespread lack of knowledge about Alzheimer’s disease through a variety of education and outreach activities.
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Neuropathology
Was it really Alzheimer’s disease? This is the most important question that the Neuropathology Component addresses upon the death of a research volunteer for the children and grandchildren who are concerned about developing dementia.
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Data Management and Statistics
Responsible for transferring our ADRC data to the National Alzheimer’s Coordinating Center which houses and makes available data from all 29 Alzheimer’s disease centers to researchers worldwide.
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Administrative
Responsible for high-level planning, coordinating the five components and any research projects funded through the ADRC, attracting and nurturing the development of new investigators, and managing all ADRC operational requirements.
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